And now.... HARD FX!!!!!

[JBerto]

Supposedly HardFX replace Hyperdrol X2 (I really LOVED it!!!), and AX promote use HardFX like a testosterone booster and anti-estrogens,... but it looks that the consensus in all the studies about D-Asp is that it can do two things: increase test AND increase estrogens

Summary. Mammalian testis contains D-aspartic acid (D-Asp), which enhances testosterone production. D-Asp, on other hand, also stimulates 17β-estradiol synthesis in the ovary of some lower vertebrates. We studied boar testis in order to determine if D-Asp intervenes in 17β-estradiol synthesis in the testis of those mammals which produce significant amounts of estrogens as well as testosterone. The boar testis contains D-Asp (40 ± 3.6 nmol/g tissue) which, according to immunohistological techniques, is localized mainly in Leydig cells, and, to a lesser extent, in sustentacular (Sertoli), peritubular and some germ cells. The enzyme P450aromatase is present in Leydig cells and few germ cells. In vitro experiments showed that the addition of D-Asp to testicular tissue extracts induced a significant increase of aromatase activity, as evaluated by testosterone conversion into 17β-estradiol. The enzyme’s Km was not affected by D-Asp (about 25 nM in both control and D-Asp added tests). On the basis of these results we suggest that, as in the ovary, D-Asp is involved in the local control of aromatase activity of boar testis and, therefore, it intervenes in the 17β-estradiol production. In the testis, the D-Asp targets are presumably the Leydig cells, which having also a nuclear estrogen receptor are, in turn, one of the putative targets of the 17β-estradiol that they produce (autocrine effect).

SpringerLink - Journal Article
(There are a lot of studies that show identical results)

If that is true (and i think that is true, because almost every study say the same: D-Asp increase test AND estrogens), then i don't understand all the recent hype with D-Asp

[admin]

Supposedly HardFX replace Hyperdrol X2 (I really LOVED it!!!), and AX promote use HardFX like a testosterone booster and anti-estrogens,... but it looks that the consensus in all the studies about D-Asp is that it can do two things: increase test AND increase estrogens

If that is true (and i think that is true, because almost every study say the same: D-Asp increase test AND estrogens), then i don't understand all the recent hype with D-Asp

The same thing can be said of forskolin, it increases steroidogenesis somewhat indiscriminately through PKA/cAMP/StAR too. That why we only used half doses them of each in HFX, to promote the synergy and effect without the same likelihood of sides that occur using high doses of either. The TST powerpacks then give the user the ability to get the 3g/day full clinical high dose if they want to.

The inclusion of 7-MF in this formula further prevents the likelihood of sides. HFX uses exactly the same dose concentration used in the in-vitro enzyme assays and recommended for humans in the vendor's studies. The problem with steroidal AI's (ATD,etc) is that they can kill the steroidogenic mechanism of DAA and forskolin, so it's futile to combine them because they fight each other. You may as well take one or the other, a cAMP booster or an AI.

[*big D*]

Ok so this isn't an area which I have much knowledge at all but just thought id lay down my opinion as normal based on what little knowledge I have gained from reading around (maybe incorrect yet maybe on the right lines).

So the male body has Testosterone and Estrogen, their is obviously a safe amount in which the male body can have without getting negative estrogenic side effects. When there are excess levels in the male body sides such as gyno etc can occur such as during steroid cycles. Of course having very low levels of estrogen can also cause negative side effects to the male body so their must be upper and lower limits before we see side effects.

What im saying is yes maybe d-asp increases estrogen but to what extent, enough to cause estrogen related side effects or just a small amount that has very little to no side effects? Im sure that estrogen rises a whole lot more during steroid cycles compared with D-asp yet only small numbers gets negative sides even without using other supps such as nolva etc after to regulate hormones.

Just to relate this to Hard fx, Hard fx uses a number of ingredients and so the other ingredients may counteract any possible negative sides possible of D-asp.

[massolic]

The same thing can be said of forskolin, it increases steroidogenesis somewhat indiscriminately through PKA/cAMP/StAR too. That why we only used half doses them of each in HFX, to promote the synergy and effect without the same likelihood of sides that occur using high doses of either. The TST powerpacks then give the user the ability to get the 3g/day full clinical high dose if they want to.

The inclusion of 7-MF in this formula further prevents the likelihood of sides. HFX uses exactly the same dose concentration used in the in-vitro enzyme assays and recommended for humans in the vendor's studies. The problem with steroidal AI's (ATD,etc) is that they can kill the steroidogenic mechanism of DAA and forskolin, so it's futile to combine them because they fight each other. You may as well take one or the other, a cAMP booster or an AI.

so if i take four caps of tst with 2 caps of hard fx in the mornings for the last four weeks of my stack, isnt that more than 3 grams of DAA and it raises estrogen? any suggestions? maybe lower the tst caps?

[admin]

That is what I would take. I mean when your T raises your E raises. That is quit normal.

[massolic]

That is what I would take. I mean when your T raises your E raises. That is quit normal.

but hard fx has AI properties to control estrogen, rite?

[admin]

Correct, it was a carefully thought out stack.

[massolic]

nice..thanks admin

[adawg]

Admin covered it pretty well. But just wanted to touch down on the fact that when in most cases when testosterone raises estrogen will raise aswell, its most important to look at the T:E ratio, oppose to jsut looking at the slight increase in estrogen.

For example, in the study done on 6-oxo(a steroidal AI) there was a slight increase in estrogen, but the increase in testosterone was much higher, keeping the T:E ratio in check and therby negating any side effects from the slightly increased estrogen. Basically when high amounts of androgens are present estrogen has less of an effect, just as if androgen levels were extremely low, it would only take a very small amount of estrogen to produce side effects.

Also in that little paragraph the MOA for estrogen increase by DAA was increased aromatase activity.....enter 7-MF. 7-MF should be more then enough to control the minor increase in aromatase activity and in that aspect should be very synergistic with DAA, possibly creating an even larger increase in test while keeping estrogen controlled.

[*big D*]

Admin covered it pretty well. But just wanted to touch down on the fact that when in most cases when testosterone raises estrogen will raise aswell, its most important to look at the T:E ratio, oppose to jsut looking at the slight increase in estrogen.
.

Hey I don't think I did too bad with clearing up the rough idea on Test+estrogen, estrogen causing sides etc :P. Think I did allright for a newbie

[adawg]

Hey I don't think I did too bad with clearing up the rough idea on Test+estrogen, estrogen causing sides etc :P. Think I did allright for a newbie

Haha yea that was a solid answer for sure, the increase in estrogen is prolly very minor, good points for sure.

[*big D*]

[massolic]

well said, AX

[Smbpd23]

Just got my Hard FX Powercell. Any need for PCT? If so recommendations.

[adawg]

Just got my Hard FX Powercell. Any need for PCT? If so recommendations.

Nope definitly not. There natural testosterone booster, when your done just make sure and take a 4-8 week break.